Inducible HSP70 Is Critical in Preventing the Aggregation and Enhancing the Processing of PMP22

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Inducible HSP70 Is Critical in Preventing the Aggregation and Enhancing the Processing of PMP22

Chaperones, also called heat shock proteins (HSPs), transiently interact with proteins to aid their folding, trafficking, and degradation, thereby directly influencing the transport of newly synthesized molecules. Induction of chaperones provides a potential therapeutic approach for protein misfolding disorders, such as peripheral myelin protein 22 (PMP22)-associated peripheral neuropathies. Cy...

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ژورنال

عنوان ژورنال: ASN Neuro

سال: 2015

ISSN: 1759-0914,1759-0914

DOI: 10.1177/1759091415569909